Adiós a la diabetes tipo 2: científicos descubren el 'interruptor' ISRIB que podría revertirla

Mariano Tovar DIABETES Descubren por qué las células no consiguen producir insulina PASO DE GIGANTE CONTRA LA

[{"selector":"#anim-f491a3db-07e8-4db4-84ce-00ea42edf55e [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 0.12345709277238391%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":8000,"fill":"both"}] [{"selector":"#anim-444e1e17-cc8b-46ae-bfa2-ec55ff767915","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Un equipo de científicos de la Universidad de Michigan ha identificado un "interruptor" celular que podría revertir la diabetes.

[{"selector":"#anim-71fe8a86-c5be-44d8-9bbd-9fe41c29993a [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 0.12345709277238391%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":8000,"fill":"both"}] [{"selector":"#anim-7ad311ba-7bc2-4dab-b847-ee374e8a808f","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] La diabetes tipo 2 se produce por la disfunción mitocondrial en células β que provoca inmadurez y producción deficiente de insulina.

[{"selector":"#anim-67c74b0b-e087-49a8-b906-88c81b2b71d9 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 0.12345709277238391%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":8000,"fill":"both"}] [{"selector":"#anim-9cf32c4c-cbc3-4e92-835d-a30b45cbccd2","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Los investigadores descubrieron una respuesta al estrés desencadenada por mitocondrias dañadas que impide que esas células funcionen correctamente.

[{"selector":"#anim-844593ad-a3b3-4e91-93d3-4dd61aef92fd","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-9cff0d3b-4964-4e84-bcdf-eafbecebf675 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 0.12345709277238391%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":8000,"fill":"both"}] Bloquearon la respuesta con ISRIB, un fármaco experimental, que reparó las células β en ratones y restauró su capacidad para controlar la glucosa.

[{"selector":"#anim-c79f9a9f-709d-4689-a170-33b1766e6f96 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 0.12345709277238391%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":8000,"fill":"both"}] [{"selector":"#anim-7c32e9c4-ed6e-4468-b80c-d5ea0436645d","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] El ISRIB inhibe la respuesta al estrés celular y también se está probando en enfermedades neurodegenerativas como el Alzheimer y el Parkinson.

[{"selector":"#anim-c20b3ef5-c346-48b0-a58b-4e8f38dbc2fa [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 0.12345709277238391%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":8000,"fill":"both"}] [{"selector":"#anim-4cf9673b-5725-426e-a679-b847d3cca830","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Los diabéticos tipo 2 no producen suficiente insulina o no pueden utilizar la que produce su páncreas para mantener niveles normales de azúcar en sangre.

[{"selector":"#anim-290788ef-3431-4d61-8fa1-07de183075e8 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-51.0638560089414%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":8000,"fill":"both"}] [{"selector":"#anim-c3865bab-7fed-4f14-b83a-13c86a6ef7ba","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Hasta ahora, ningún estudio había explicado por qué las células β no conseguían madurar y producir insulina.

[{"selector":"#anim-23bacaee-0977-40bb-b2dd-3d2944d1ece3 [data-leaf-element=\"true\"]","keyframes":{"transform":["scale(0.847457627118644)","scale(1)"]},"delay":0,"duration":8000,"fill":"forwards"}] [{"selector":"#anim-cf97a6b2-8503-41a1-ba00-17626fbec562","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-60fcdd28-7645-43f3-bc5b-2d632b48711f","keyframes":{"transform":["translate3d(131.99998%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] “Queríamos determinar qué vías son importantes para mantener la función mitocondrial adecuada”, dijo la doctora Emily M. Walker, miembro del equipo.

[{"selector":"#anim-c54befb2-36de-4bac-b5e2-33d21833dc55 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-31.21247445907036%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":8000,"fill":"both"}] [{"selector":"#anim-b6ac35dd-2986-48fc-b655-085b7933bf5d","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] La diabetes afecta a varios sistemas: aumentas de peso, el hígado produce demasiada azúcar, los músculos se ven afectados...

[{"selector":"#anim-f7f185af-0c2e-4e6e-933e-6ec5f60afcb0 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(0, 0.12345709277238391%, 0)","translate3d(0, 0%, 0)"]},"delay":0,"duration":8000,"fill":"both"}] [{"selector":"#anim-797edd36-469c-47c4-ada2-45c4af8dd069","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d2a70973-c119-4e47-98cf-890f6faf9097","keyframes":{"transform":["translate3d(111.33332%, 0px, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] “Ahora tenemos una explicación de lo que está sucediendo y cómo podemos solucionar la causa raíz”, afirmó el Dr. Soleimanpour autor principal del estudio.

[{"selector":"#anim-0c41f8f1-86d7-4f9a-9630-163679672896 [data-leaf-element=\"true\"]","keyframes":{"transform":["translate3d(-15.41617176259678%, 0, 0)","translate3d(0%, 0, 0)"]},"delay":0,"duration":8000,"fill":"both"}] [{"selector":"#anim-3d58df9f-89d1-4ee1-aeb2-fb46a1f77deb","keyframes":{"opacity":[0,1]},"delay":0,"duration":2000,"easing":"cubic-bezier(0.4, 0.4, 0.0, 1)","fill":"both"}] Los investigadores esperan replicar estos resultados en células de pacientes diabéticos y abrir nuevas vías para curar la enfermedad.

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